Dr. Chris Palmer: Diet & Nutrition for Mental Health

My guest this episode is Chris Palmer, M.D., a board-certified psychiatrist and assistant professor of psychiatry at Harvard Medical School. He explains the important connection between nutrition, metabolism and mental health and his pioneering work using the ketogenic diet to successfully treat patients with various mental illnesses, including depression and schizophrenia. Dr. Palmer explains how the ketogenic diet is an evidenced-based treatment for epilepsy, mimics the fasted state and can offset the cognitive decline in Alzheimer’s. He describes the key roles of mitochondria in mental health, how certain conditions likely arise from mitochondrial dysfunction, and how low-carbohydrate diets increase mitochondrial turnover to improve mental health. He also explains how low-carbohydrate diets positively impact the gut microbiome and weight loss, important risk factors for mitochondrial health such as marijuana and alcohol, and the best way to increase circulating ketones depending on individual needs. We also cover how a ketogenic diet impacts mood, sleep, and fertility. Dr. Palmer’s work stands as a revolutionary approach to mental health and disease that, given the prevalence of mental health challenges, should be of interest to people of all backgrounds and ages.

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Dr. Chris Palmer
Dr. Palmer’s website: https://www.chrispalmermd.com
Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health–and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More: https://amzn.to/3XheFIV
Medical profile: https://www.mcleanhospital.org/profile/christopher-palmer
Academic profile & publications: https://connects.catalyst.harvard.edu/Profiles/display/Person/70255
Twitter: https://twitter.com/ChrisPalmerMD
Instagram: https://www.instagram.com/chrispalmermd

Timestamps
00:00:00 Dr. Chris Palmer, Mental Health & Metabolic Disorders
00:03:25 Thesis, Eight Sleep, ROKA
00:07:18 Nutrition & Mental Health
00:20:43 Low-Carb Diets & Anti-Depression, Fasting, Ketosis
00:27:52 Schizophrenia, Depression & Ketogenic Diet
00:34:32 AG1 (Athletic Greens)
00:35:38 Psychiatric Mediations, Diet Adherence
00:42:35 Highly Processed Foods, Ketones & Mental Health Benefits
00:46:51 Ketogenic Diet & Epilepsy Treatment
00:56:10 Ketogenic Diet & Mitochondria Health
00:57:05 Nutrition & Benefits for Neurologic/Psychiatric Disorders
01:05:44 Mitochondrial Function & Mental Health
01:15:12 InsideTracker
01:16:23 Mitophagy, Mitochondrial Dysfunction, Aging & Diet
01:25:09 Neurons, Mitochondria & Blood Glucose
01:31:54 Obesity, Ketogenic Diet & Mitochondria
01:40:00 Mitochondrial Function: Inheritance, Risk Factors, Marijuana
01:46:34 Alcohol & Ketogenic Diet
01:55:21 Brain Imaging, Alzheimer’s Disease & Ketones
02:01:05 Exogenous (Liquid) Ketones vs. Ketogenic Diet
02:06:27 Neuronal Damage, Ketones & Glucose
02:10:16 Alzheimer’s Disease, Age-Related Cognitive Decline & Ketogenic Diet
02:23:45 Ketogenic Diet & Weight Loss
02:35:47 Ketogenic Diet & Fasting, Hypomania, Sleep
02:46:37 Low Carbohydrate Diets, Menstrual Cycles, Fertility
02:52:23 Obesity Epidemic, Semaglutide & GLP-1 Medications
03:01:01 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Social Media

Huberman Lab is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

Title Card Photo Credit: Mike Blabac – https://www.blabacphoto.com

49 Comments

  1. My story is just like Dr. Palmer's, except I was diagnosed with bipolar type 2 at age 20. The first med worked for me for 8 yrs then stopped working. Nothing worked after that, and a medication called vraylar made me gain >80lbs in a yr and I got metabolic syndrome and it made me diabetic. The diabetes meds wouldn't help until stopping vraylar.

    After being off it 1yr the diabetes reversed, but I remain very insulin resistant, even on mounjaro but I've lost 62lbs. I fast until after lunch.

    I'm Gen X, grew up on poptarts, very picky and never had many vegetables and hate them. I love carbs, some protein, and I live alone and can't cook so processed packaged foods are what I live on. I feel trapped by that because I could never give them up. It looks like they're tying brain inflammation to mental illnesses like bipolar.

    I'm also looking into genetic variants, and I have lots of double variants including COMT & MTHFR, the ones affecting mood. I think Nutrient Therapy can help people too.

  2. My faith in Jesus is greatly helping my established diagnosis of schizoaffective disorder — keep on the medication, introducing exercise more now and a better diet.

  3. I just happen to have watch Dr. Robert Lustig just before this one and it was extremely rich to connect how fructose seem to cause mitochondria disfunction based on what he said and Dr. Palmer not yet (it might be that studies were publish later) being convinced that sugar (he didn't make the difference between glucose and fructose) has a causal effect on mitochondria disfunction. All your podcasts are rich in themselves, can are even more powerful when combining them. 🙏

  4. As a psych NP in community mental health the story of the fellow with schizoaffective finally having insight made me tearful it was such a powerful story.

  5. On your tv time is around at 31:00 and you talk about a disorder about a man—- well it is a true technology and it is so very real and the reason it is getting better is because the drugs that they gave him is wearing off or they are stopping to torturing him and it is called no touch torture through radio frequencies this has been going on for decades and people can’t prove it so it looks like that the person is crazy it is almost like Havana syndrome,,, there is a support group that this technology is happening to millions of people right now and again we all can’t prove it ,,, there’s no drugs that can work unless you are sedated or death,, all the doctors in the world is hard to convince about this technology and it’s happening right under every one’s nose,,, if you want more information about this real technology try to get intouch with me…

  6. I think it is called targeting justice support group, just keep on looking and you’ll find the groups that it is happening all over the world… the other names are called no touch torture though the internet with radio frequency’s being controlled by a group of individuals and again that no one can prove it because radio frequency’s are invisible

  7. I can’t imagine that Andrew will get this message however with regards to Alzheimer’s I have three parents who suffered with serious mental decline/alzheimers and I can attest to the fact that their diets were HIGH in carbs to the point of watching them eat sweets like it was going out of style….an insatiable need for sugar (ice cream,candies, cookies etc). I have seen this over and over that these patients in particular just can’t seem to get enough sugar. I understand that the low carb diet trials are hard to do but I would rather see a Carnivore trial. My concern is the “oxylates” and “phytates and lectins” that can yet be present in a low carb diet which could skew positive results. I listen to many podcasts and I am presently on Carnivore. The results I am hearing from the Carnivore camp with regards to Alzheimers is VERY positive

  8. Thanks, Dr H for this interview. Chris Palmer has such an incredibly open mind in the way in thinks about causation and medicine in the smallest and biggest views possible of our internal systems. Brilliant!

  9. This was phenomenal. I've been looking for possible treatments for long term cognitive compromise from chemotherapy. Would love to find or participate in a study of keto treatment for that.

  10. 20 years ago, I got rid of a 15 year struggle with epilepsy through the Atkins diet. I’m a massive believer in it for mental illness. I not only had epilepsy but was so depressed at that time, I had a nervous breakdown. Within 1 month of doing Atkins (modified, healthier version — no bacon or red meat, tons of veggies, fish, poultry, eggs, more veggies, healthy fats, unsweetened greek yogurt, etc.), I was not only seizure free, but also free of depression WITHOUT meds. I still eat extremely low carb compared to most people, although I do eat more fruit now. Anytime I start to feel blue again, I’ll pull back and implement more protein, healthy fats, and nonstarchy veggies. I haven’t touched sugar (added sugar) in the last 20 years after that experience. It really is that bad for your brain and body. Never doubt the power of food. It controls everything you do, feel, and how you show up in the world.

  11. It’s so disappointing to hear doctors talk about mental health issues and never dealing with Anger, resentment and hostility… I was depressed for over 12 years and I had a pastor mention that anger and resentment could be a cause of depression… as soon as I gave up my resentment, anger and hostility and learned to forgive… my depression and mental health issues lifted… I do believe diet is Important and when we have a clear mind we will make good health food choices… unhealthy foods changes our chemistry and can cause mental illnesses…

  12. I wished I could hug you so tight Dr Palmer! You are amazing and because of you I have a clearer vision of what steps to take next for my mental health and metabolic system

  13. Anorexia isn't the most deadly mental illness. 25% of all Bipolar patients commit suicide. Fasting 2+ days- YOU MUST SUPPLEMENT ELECTROLYTES! Theres an increasing risk of kidney and heart failure the longer you go without them. They have 0 calories or carbs so won't stop your fast. Don't take the full daily amount at once, take several small doses or it's not safe either.

  14. Nice. Informative. …

    On the presentation level. One can learn to speak with a less 'nasal' voice. Sounds becoming annoyingly intrusive diminish the impact of the content. …

    On the content level. Container numbers – hundreds of thousands, … – make the content less specific. Or 'precise' numbers, or none. … And the 'calorie restriction' hallo seems out-dated. … And then around 1:36:00 the Godzilla-trillion-tremendous question about obesity. And here one gets a splendid example of 'bad' reasoning, hip-hopping trough the 80's and 70's to the 40's and 30's 'diet' without any specific or precise historic analysis of – inter alia – eating habits of social classes, food and farming production conditions and procedures, use of artificial additives of whatever kind, more natural product replacements – stevia for sugar or transfat oil for olive oil -, … to name just 3. The poorer the more likely to be obese. The more standard American diet – overloaded with chemical stuff – the more likely to become obese. The more weed killing pesticides in mono-cultures used in the food chain, the more likely to become obese. No 'real' cause for the epidemic of obesity, 'really' ? What a laughing stock !

    But, overall, interesting.

  15. Rating: 8.3/10
    In short: Metabolism and Psycosis, an interesting connection
    Notes: Chris is an outspoken and well spoken doctor who is pioneering the keto diet for psychiatric illnesses. He has a lot of powerful anecdotal stories, and mechanism, that gives his theories strength and backing. The nuance and not just blind faith in keto diet to help ppl was good. Chris referenced many studies but didn’t say many names of ppl in the field which was ok, and it seemed like a lot of chris/huberman were just begging for more studies. The politics of science and realities of treating patients came through this podcast and was interesting as well. And the idea that metabolic syndrome and obesity are brain/mental illnesses is kind of profound and scattered throughout this podcast, but never explicitly stated. Would have been nice, the environmental vs. genetic talk of being fat.

  16. Thank you for sharing phenomenal discussion and insights of mitophagy / improving mitochondria impairment by simple lifestyle changes, leading to cure for major illness including mental illness ! If I may I would like to ask if these lifestyle changes that were mentioned could cure the allergies as well. I have been developing strong pollen allergies where I cannot eat all the fruits both fresh and cooked and part of vegetables even with the medication I take. Only I hear is that this will get worsen over time and it would be great to hear if there is any study related to it.

  17. I really appreciated you touching on epilepsy during this talk. I usually listen to you and follow you on My Amazon Podcasts, but I was passionate about making a comment today, hence why I came onto YouTube , it would be great if you did some more Epilepsy related topics as we have such a diverse range of people with epilepsy around the world. Thank you for your guidance and advice and everything. Caz

  18. Seeds and vegetable oils are killing us. Most processed foods have them. Watch Dr Bergs video entitled "The worst ingredient in the world" with Dr Chris Knobbe

  19. Cognitive psychologists always overlook diet and nutrition ,even the king of cognitive psychology Albert Ellis claimed to cure anxiety completely but i still have not read about someone getting cbt or rebt who was completely cured of these things and cognitive psychologists advice some witchcraft like cognitive distortions etc .I hope Dr Hubermann invites some fierce critics of cognitive psychology someday . I was going through so much emotional pain during the last year and have read and applied books from cognitive psychology and also i have interacted with cognitive psychologists through email ,thanks for them to reply back but the field is a witchcraft , but there is a difference that witchcraft might still work a bit .
    I really hope in the future we will have therapies which actually work instead of wasting years and years like CBT ,REBT and similar therapies and still no complete cure , it will be a good change .

  20. I’m curious about the financial barriers of the individuals you treated in adapting these diet changes. Working in the mental health field I’m astonished at being able to sustain a specific diet between financial barriers, access to appropriate kitchen facilities, cooking skills, having the capacity to follow a specific diet with people who have been clinically unstable and already through numerous treatments and psychiatrists. In my experience most (not all) people in those situations have housing and other financial barriers that would just make adherence to a specific diet very very very difficult.

    I worked in a small low barrier homeless shelter and we were always walking the line of healthy cooking and food people would actually eat because they were so used to highly processed convenience food. The people in the shelter often had difficulty even adapting to a home cooked meal.

  21. This is my low-carbohydrate diet story.

    In 2013, I developed acne that would not go away no matter how low in fat I ate.

    In 2014, I ate a low-carbohydrate diet of eggs, chicken thighs, 85/15 ground beef, avocados, and coconut oil, and my acne went away immediately and I enjoyed the diet.

    In 2019, I had my first lipid panel done and my cholesterol was extremely high and I subsequently found out I was a carrier of an ApoE4 allele and had cholesterol hyperabsorption mutations in my ABCG5 and ABCG8 genes.

    So I avoided egg yolks and saturated fats and ate lean meats, egg whites, olive oil, avocados, and macadamia nuts for the next 5 years, and my cholesterol returned to normal, but everything was unpalatable and I was always in a bad mood.

    Recently I decided to take a cholesterol lowering medication and to reincorporate whole eggs and meat with its fat while reducing my consumption of olive oil and macadamia nuts and my mood has improved incredibly.

    I will no longer avoid egg yolks or animal fat and will rather take a cholesterol lowering medication.

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