Top Treatments for Major depressive disorder | Clinical Practice guidelines

Top Treatments for Major depressive disorder | Clinical Practice guidelines

In this video, we discuss medications used as treatment for Major Depressive Disorder and what the recent treatment guidelines suggest as first-line treatments which include second-generation antidepressants such as SSRIs, SNRIs, NDRI’s, and Multi-modal antidepressants. Top medications from each of these classes are discussed including potential side effects.

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Intro 0:00
Considerations 00:33
SSRIs 01:26
SNRIs 05:29
Atypical antidepressants:
Bupropion 08:29
Vortioxetine 09:45
Mirtazapine 10:55
Rare and Dangerous side effects 12:41
Takeaways 16:52

Resources:
Deprescribing Guide: https://amzn.to/4dZEUMk
Stahl’s Prescribing Guide: https://amzn.to/3UXj8QL

Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice, or substituted for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own health care provider for proper diagnosis and treatment.

References:
American Psychological Association (APA). (2019). Clinical practice guideline for the treatment of depression across three age cohorts. APA.org. Retrieved from https://www.apa.org/depression-guideline
Bjarnadottir, A. (2018, December 4). A guide to common antidepressant side effects. Healthline. Retrieved from https://www.healthline.com/health/antidepressant-side-effects
Hirsch, M., & Birnbaum, R. J. (2019) Sexual dysfunction caused by selective serotonin reuptake inhibitors (SSRIs): Management. Up To Date. Retrieved from https://www-uptodate-com.libproxy.eku.edu/contents/sexual-dysfunction-caused-by-selective-serotonin-reuptake-inhibitors-ssris-management?search=Sexual%20dysfunction%20caused%20by%20selective%20serotonin%20reuptake%20inhibitors%20(SSRIs):%20Management&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1
Kennedy, S. H., Lam, R. W., McIntyre, R. S., Tourjman, S. V., Bhat, V., Blier, P., Hasnain, M., Jollant, F., Levitt, A. J., MacQueen, G. M., McInerney, S. J., McIntosh, D., Milev, R. V., Müller, D. J., Parikh, S. V., Pearson, N. L., Ravindran, A. V., Uher, R., & CANMAT Depression Work Group (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical guidelines for the management of adults with major depressive disorder: Section 3. Pharmacological treatments. Canadian Journal of Psychiatry, 61(9), 540–560. https://doi-org.libproxy.eku.edu/10.1177/0706743716659417
Rush, J.A (2020). Unipolar major depression in adults: Choosing initial treatment. Up to Date. Retrieved from https://www-uptodate-com.libproxy.eku.edu/contents/unipolar-major-depression-in-adults-choosing-initial-treatment?search=antidepressants&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2
Stahl, S. (2017). Stahl’s essential psychopharmacology: prescribers guide (6th ed.). New York,
N.Y.: Cambridge University Press.

This video was created using the following:
Doodly v2.6.3
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Adobe Premiere- editing software