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How Diet Can Treat Depression: The Metabolic Marvel of Bile Acids



How Diet Can Treat Depression: The Metabolic Marvel of Bile Acids

Metabolic health is the foundation for mental health. We are only beginning to unravel the mechanistic mysteries around the ways in which how we eat and live as physical beings impacts our mind. These new data add an interesting piece to the puzzle and demonstrate how bile acid molecules act as endogenous anti-depressants. Watch all the way through, and you’ll be astonished at the biological elegance of our bodies. And you’re in for a surprise.

Chapters
0:00 – Metabolic Psychiatry is Booming
0:47 – Bile Acids Can Improve Depression
4:51 – How this relates to Your Mental Health
6:07 – What Fuels Metabolic Psychiatry?
6:47 – People Don’t Fake Depression, They Fake Being Okay
7:22 – Words from Zach Williams

Prior Keto and Bile Acids video: https://youtu.be/d0WuCIZxPxU

Optogenetics is covered in this video shortly after the 3-minute mark: https://youtu.be/44qM9VtNAjc

Danan et al. paper: https://pubmed.ncbi.nlm.nih.gov/35873236/

Sethi el al. paper: https://pubmed.ncbi.nlm.nih.gov/38547601/

Sethi et al. video review: https://youtu.be/Gpz_uOHluWo

#mentalhealth #depression #metabolism #ketodiet #anxietyrelief

View 21 Comments

21 Comments

  1. @douglashenson4793 on

    It is heart breaking that Robin Williams suffered in secret. For all that he gave us, we could not help him. Thank you Nick for your tribute and thank you for having his son speak. I think there is hope now since the shocking loss of Robin Williams which may have helped propel new research into mental illness and how diet, gut biome, and metabolic health are key factors and may be the most important factors.

  3. @brcage on

    This makes so much sense.. i was hit with debilitating OCD/Instrusive thoughts which has ruined my life, after being forced to take anti-acid long term due to a hiatal hernia i developed…

  7. @mmanda515 on

    Love this & agree. I also think for those following keto or carnivore, cutting out all the ultra processed chemicals & garbage in 'foods' these days helps tremendously too. Otherwise, it's like putting diesel in a gas engine. Worse & worse over time, the entire car will fail.

  11. @TemoteControl on

    Can speak from experience – anytime I fall of keto/carnivore – my mental health deteriorates.. diagnose bipolar and have found so many benefits with ketosis… working to heal my addiction to carbs and sugar…

  16. @TheCuratorIsHere on

    All those are directly caused by hyperinsulinemia. It is so obvious 🙄

    This also explains why it is relative to individual’s genetics as is the insulin response.

    This also explains why some people do better on vegan or keto or carnivore => individual variation in insulin response. Possibly also modulated by the micro biome’s ability to break down nutrients that raise insulin response.

    It’s baffling that this has been discovered a long time ago and is yet to be disproven. That it links to all those issues and explains all the conflicting evidences — as this is the missing link in the context to explain the opposing results. This explains why population studies will never find this out as it’s an individual response.

    This explains the wide variety of chronic illness arising from metabolism dysfunction with various names based on which organ fails first.

    Educate yourself people.

  17. @ProdicleSon. on

    I’ve been carnivore/keto for the last year after suffering for 8 years with mental health issues caused by poor lifestyle choices such as eating junk food, drinking too much and not getting enough sleep. My body and mind had enough and I physically could not function anymore. I tried different antidepressants and exercise but it was like putting a band aid over a massive gash. It didn’t work. My last try was to give the carnivore diet a go and after that first steak I had my life has changed in ways I could never imagine. I could feel my brain turning on again. I could laugh and be present like I once could when I was younger. I dove deep into this issue of how diet has such a profound impact on our mental health and try to spread this information. It’s only a matter of time until this becomes mainstream and people can finally start to heal themselves without using all these pharmaceuticals that don’t even address the issue. The issue being our habits and lifestyle choices.

  19. @lewynld on

    I am completely confounded by Nick's caloric intake during his experiments and how he can fail to gain weight. Could you please consider sharing metabolic labs in a future video?

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